Scientists from SFU (Southern Federal University) have developed a new method for obtaining antibiotics of the quinolone series, a group of drugs that exhibit bactericidal action. Russian chemists have proposed a simpler and single-stage method of obtaining quinolone derivatives from readily available substances.
Due to the constant mutation of bacteria and viruses, antibiotics lose their effectiveness. Chemists explain that drugs of the quinolone class, used since the 1960s in clinical practice, differ from other antimicrobial drugs in their mode of action, which ensures their activity against resistant strains of microorganisms.
The scientists aimed to find a simpler approach to the synthesis of quinolone derivatives. They reduced the number of stages for obtaining these substances from readily available materials. The main difference in this approach from existing analogs is that it suggests expanding the cycle rather than closing it. The modernization of the technology allows for reducing the cost of drugs of this class on the market by more than 10% and provides a simpler way to search for new antibiotics.
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